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Inhibitors for E3 ubiquitin ligases

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Two studies show that specific cullin-RING E3 ubiquitin ligases can be targeted with small molecules.

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Figure 1: Allosteric inhibition of SCFCdc4 by SCF-I2.

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Authors and Affiliations

  1. John R. Lydeard and J. Wade Harper are in the Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA.,

    John R Lydeard & J Wade Harper

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  1. John R Lydeard
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  2. J Wade Harper
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Correspondence to J Wade Harper.

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The authors declare no competing financial interests.

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Lydeard, J., Harper, J. Inhibitors for E3 ubiquitin ligases. Nat Biotechnol 28, 682–684 (2010). https://doi.org/10.1038/nbt0710-682

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