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Biomarker validation by targeted mass spectrometry

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A multilaboratory study demonstrates the potential for establishing quantitative targeted proteomic assays for moderately to highly abundant plasma proteins.

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Figure 1: The relationship between tandem mass spectrometry (MS/MS) and multiple-reaction monitoring (MRM).

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Authors and Affiliations

  1. Martin McIntosh and Matthew Fitzgibbon are in the Computational Biology and Molecular Diagnostics Programs at the Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.,

    Martin McIntosh & Matthew Fitzgibbon

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  1. Martin McIntosh
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  2. Matthew Fitzgibbon
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Correspondence to Martin McIntosh.

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McIntosh, M., Fitzgibbon, M. Biomarker validation by targeted mass spectrometry. Nat Biotechnol 27, 622–623 (2009). https://doi.org/10.1038/nbt0709-622

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