Skip to main content

Advertisement

SpringerLink
Log in

Putting immunoinformatics to the test

  • News & Views
  • Published:

From Nature Biotechnology

View current issue Submit your manuscript

A consensus epitope prediction approach identifies the epitopes responsible for 95% of the murine T-cell response to vaccinia virus.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: The traditional approach to epitope mapping the vaccinia genome would involve synthesizing almost 176,000 overlapping 8-mer, 9-mer and 10-mer peptides (gray).

Bob Crimi

References

  1. Moutaftsi, M. et al. Nat. Biotechnol. 24, 817–819 (2006).

    Article  CAS  Google Scholar 

  2. Santori, F.R., Brown, S.M. & Vukmanovic, S. Immunol. Rev. 190, 146–160 (2002).

    Article  CAS  Google Scholar 

  3. Inaba, H. et al. J. Clin. Endocrinol. Metab. 91, 2286–2294 (2006).

    Article  CAS  Google Scholar 

  4. Westritschnig, K. & Valenta, R. Curr. Opin. Allergy Clin. Immunol. 3, 495–500 (2003).

    Article  CAS  Google Scholar 

  5. Ely, L.K. et al. J. Immunol. 174, 5593–5601 (2005).

    Article  CAS  Google Scholar 

  6. Wu, Z. et al. Nat. Med. 10, 87–92 (2004).

    Article  CAS  Google Scholar 

  7. Mallone, R. & Nepom, G.T. Clin. Immunol. 110, 232–242 (2004).

    Article  CAS  Google Scholar 

  8. De Groot, A.S., Knopf, P.M. & Martin W. De-immunization of therapeutic proteins by T cell epitope modification. In State of the Art Analytical Methods for the Characterization of Biological Products and Assessment of Comparabilitiy. (ed. Mire Sluis, A.) Vol 122. pp 137–160 (Dev. Biol. Basel, Karger, 2005).

  9. Lazarski C.A. et al. Immunity 23, 29–40 (2005).

    Article  CAS  Google Scholar 

  10. pasquetto V. et al. J. Immunol. 175, 5504–5515 (2005).

    Article  CAS  Google Scholar 

  11. Kim, S.K. et al. J. Exp. Med. 201, 523–533 (2005).

    Article  CAS  Google Scholar 

  12. Nagayama Y. et al. J. Immunol. 173, 2167–2173 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Brown Medical School, 70 Ship Street, Providence, 02903, Rhode Island, USA

    Leonard Moise & Anne S De Groot

  2. EpiVax, Inc., 146 Clifford Street, Providence, 02903, Rhode Island, USA

    Leonard Moise & Anne S De Groot

Authors
  1. Leonard Moise
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anne S De Groot
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Moise, L., De Groot, A. Putting immunoinformatics to the test. Nat Biotechnol 24, 791–792 (2006). https://doi.org/10.1038/nbt0706-791

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt0706-791

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation