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Summary recommendations for standardization and reporting of metabolic analyses

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The Standard Metabolic Reporting Structures (SMRS) working group outlines its vision for an open,community-driven specification for the standardization and reporting of metabolic studies.

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References

  1. Lindon, J.C. (ed.). Standardisation of Reporting Methods for Metabolic Analyses: a Draft Policy Document from the Standard Metabolic Reporting Structures (SMRS) Group (Imperial College, London, UK, 2005). http://www.smrsgroup.org/documents/SMRS_policy_draft_v2.3.pdf

    Google Scholar 

  2. Nicholson, J.K., Connelly, J., Lindon, J.C. & Holmes, E. Nat. Rev. Drug Disc. 1, 153–161 (2002).

    Article  CAS  Google Scholar 

  3. Fiehn, O. Plant Mol. Biol. 48, 155–171 (2002).

    Article  CAS  Google Scholar 

  4. http://www.pharmquest.com/send_consortium/overview.htm

  5. http://www.chem.qmw.ac.uk/iupac

  6. http://www.genome.ad.jp/kegg/

  7. Gullberg, J., Jonsson, P., Nordström, A., Sjöström, M. & Moritz, T. Anal. Biochem. 331, 283–295 (2004).

    Article  CAS  Google Scholar 

  8. Markley, J.L. et al. J. Mol. Biol. 280, 933–952 (1988).

    Article  Google Scholar 

  9. Davies, A.N. et al. Pure Appl. Chem. 73, 1749–1764 (2001).

    Article  CAS  Google Scholar 

  10. Wilkins, L. Pure Appl. Chem. 67, 593–596 (1995).

    Article  CAS  Google Scholar 

  11. Harris, R.K., Becker, E.D., de Menezes, S.C., Goodfellow, R. & Granger, P. Pure Appl. Chem. 73, 1795–1818 (2001).

    Article  CAS  Google Scholar 

  12. Johansson, E., Wold, S. & Sjödin, K. Anal. Chem. 56, 1685–1688 (1984).

    Article  Google Scholar 

  13. Jonsson, P. et al. Anal Chem. 76, 1738–1745 (2004).

    Article  CAS  Google Scholar 

  14. Bino, R.J. et al. Trends Plant Sci. 9, 418–425 (2004).

    Article  CAS  Google Scholar 

  15. Jenkins, H. et al. Nat. Biotechnol. 22, 1601–1606 (2004).

    Article  CAS  Google Scholar 

  16. German, J.B., et al. J. Nutr. 134, 2729–2732 (2004).

    Article  CAS  Google Scholar 

  17. http://www.fda.gov/cder/guidance/5900dft.doc

  18. http://www.epa.gov/osa/genomics.htm

  19. Xirasagar, S. et al. Bioinformatics 20, 2004–2015 (2004).

    Article  CAS  Google Scholar 

  20. http://www.mged.org

  21. http://psidev.sourceforge.net

  22. Sansone, S.A., Morrison, N., Rocca-Serra, P. & Fostel, Comp. Funct. Genomics 5, 633–641 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biomedical Sciences Division, Biological Chemistry, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, UK

    John C Lindon, Jeremy K Nicholson, Elaine Holmes, Hector C Keun, Andrew Craig, Jake T M Pearce & Stephen J Bruce

  2. Department of Computer Science, University of Wales, Aberystwyth, SY23 3DB, UK

    Nigel Hardy

  3. The European Bioinformatics Institute, EMBL Outstation, Wellcome Trust Genome Campus, Hinxton, CB10 1SD, Cambridge, UK

    Susanna-Assunta Sansone

  4. Research Group for Chemometrics, University of Umeå, Umeå, SE-901 87, Sweden

    Henrik Antti & Par Jonsson

  5. Centre for Analytical Biosciences, School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK

    Clare Daykin

  6. MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK

    Mahendra Navarange

  7. Division of Systems Toxicology, Center for Metabolomics, National Center for Toxicological Research, Food and Drug Administration, Jefferson, 72079, Arkansas, USA

    Richard D Beger

  8. TNO Pharma, Utrechtseweg 48, PO Box 360, Zeist, 3700AJ, The Netherlands

    Elwin R Verheij

  9. Sanofi-Aventis, Drug Safety Evaluation, Mainzer Landstrasse 50, Hattersheim, 65795, Germany

    Alexander Amberg

  10. NovoNordisk A/S, Novo Nordisk Park, Måløv, DK-2760, Denmark

    Dorrit Baunsgaard

  11. Bristol-Myers Squibb, PO Box 5400, Princeton, 08543, New Jersey, USA

    Glenn H Cantor & Lois Lehman-McKeeman

  12. Umetrics UK Ltd., Woodside House, Woodside Road, Winkfield, SL4 2DX, Windsor, UK

    Mark Earll

  13. Umetrics, Tvistevägen, 48 Box 7960, Umeå, SE-907 19, Sweden

    Svante Wold & Erik Johansson

  14. Safety Assessment, GlaxoSmithKline, Park Road, Ware, SG12 0DP, Hertfordshire, UK

    John N Haselden

  15. Department of Toxicology and Drug Disposition, Lilly Development Centre, Parc Scientifique de Louvain-la-Neuve, Rue Granbonpre 11, Mont-Saint-Guibert, B-1348, Belgium

    Kerstin Kramer

  16. Investigative Toxicology, Lilly Research Laboratories, 2001 W. Main St., Greenfield, 46140, Indiana, USA

    Craig Thomas

  17. Molecular Toxicology, Safety Assessment, AstraZeneca, Södertälje, Sweden

    Johann Lindberg & Ina Schuppe-Koistinen

  18. Department of Drug Metabolism and Pharmacokinetics, AstraZeneca, Mereside, Alderley Park, Macclesfield, SK10 4TG, Cheshire, UK

    Ian D Wilson

  19. Pfizer Global R&D, 2800 Plymouth Road, Ann Arbor, 48105, Michigan, USA

    Michael D Reily & Donald G Robertson

  20. Department for Biostructural Research, Hoffmann LaRoche AG, Grenzacher Str., Basel, CH-4070, Switzerland

    Hans Senn

  21. Metanomics GmbH & Co. KGaA, Tegeler Weg 33, Berlin, 10589, Germany

    Arno Krotzky

  22. Nestle Research Center, BioAnalytical Science, Lausanne, 26, CH-1000, Switzerland

    Sunil Kochhar

  23. Corporate Research, Unilever Research Laboratory, Colworth, Sharnbrook, MK44 1LQ, Bedford, UK

    Jonathan Powell & Frans van der Ouderaa

  24. Waters Life Sciences R&D Group, 34 Maple Street, Milford, 01757, Massachusetts, USA

    Robert Plumb

  25. Bruker BioSpin GmbH, Silberstreifen 4, Rheinstetten, 76287, Germany

    Hartmut Schaefer & Manfred Spraul

Consortia

The Standard Metabolic Reporting Structures working group

  • John C Lindon
  • , Jeremy K Nicholson
  • , Elaine Holmes
  • , Hector C Keun
  • , Andrew Craig
  • , Jake T M Pearce
  • , Stephen J Bruce
  • , Nigel Hardy
  • , Susanna-Assunta Sansone
  • , Henrik Antti
  • , Par Jonsson
  • , Clare Daykin
  • , Mahendra Navarange
  • , Richard D Beger
  • , Elwin R Verheij
  • , Alexander Amberg
  • , Dorrit Baunsgaard
  • , Glenn H Cantor
  • , Lois Lehman-McKeeman
  • , Mark Earll
  • , Svante Wold
  • , Erik Johansson
  • , John N Haselden
  • , Kerstin Kramer
  • , Craig Thomas
  • , Johann Lindberg
  • , Ina Schuppe-Koistinen
  • , Ian D Wilson
  • , Michael D Reily
  • , Donald G Robertson
  • , Hans Senn
  • , Arno Krotzky
  • , Sunil Kochhar
  • , Jonathan Powell
  • , Frans van der Ouderaa
  • , Robert Plumb
  • , Hartmut Schaefer
  •  & Manfred Spraul

Corresponding author

Correspondence to John C Lindon.

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The Standard Metabolic Reporting Structures working group. Summary recommendations for standardization and reporting of metabolic analyses. Nat Biotechnol 23, 833–838 (2005). https://doi.org/10.1038/nbt0705-833

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  • DOI: https://doi.org/10.1038/nbt0705-833

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