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A new path to the cancer epigenome

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A regulator of the spatial organization of chromatin may be a promising target to curb the invasiveness of breast cancer.

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Figure 1: SATB1 (orange), which forms a three-dimensional cage-like network surrounding dense regions of chromatin and is induced during progression of breast cancer, probably tethers multiple gene loci onto its regulatory scaffold and assembles them with chromatin-remodeling complexes (red) and transcription factors.

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Authors and Affiliations

  1. Victoria M. Richon is in the Department of Cancer Biology and Therapeutics, Merck Research Laboratories, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA. victoria_richon@merck.com,

    Victoria M Richon

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  1. Victoria M Richon
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Competing interests

V.M.R. is an employee of Merck & Co., Inc. and holds stock in that company.

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Richon, V. A new path to the cancer epigenome. Nat Biotechnol 26, 655–656 (2008). https://doi.org/10.1038/nbt0608-655

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