Skip to main content
SpringerLink
Log in

Reverse engineering gene regulatory networks

  • News & Views
  • Published:

From Nature Biotechnology

View current issue Submit your manuscript

An information theoretic algorithm that prunes away potentially indirect interactions allows for improved reconstruction of biological networks.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Comparison of the performance of ARACNe and a Bayesian network inference algorithm in reverse engineering a synthetic gene regulatory network.

Bob Crimi

References

  1. Basso, K. et al. Nat. Gen. 37, 382–390 (2005).

    Article  CAS  Google Scholar 

  2. Butte, A.J. & Kohane, I.S. Pac. Symp. Biocomput. 2000, 418–429 (2000).

    Google Scholar 

  3. Butte, A.J., Tamayo, P., Slonim, D., Golub, T.R. & Kohane, I.S. Proc. Natl. Acad. Sci. USA 97, 12182–12186 (2000).

    Article  CAS  Google Scholar 

  4. Barabasi, A.L. Linked: How Everything Is Connected to Everything Else and What It Means (Plume, New York, NY, 2003).

    Google Scholar 

  5. The Gene Ontology Consortium. Gene Ontology: tool for the unification of biology. Nat. Gen. 25, 25–29 (2000).

  6. Smith, V.A., Jarvis, E.D. & Hartemink, A.J. Bioinformatics 18, S216–S224 (2002).

    Article  Google Scholar 

  7. Yu, J., Smith, V.A., Wang, P.P., Hartemink A.J. & Jarvis, E.D. in 3rd International Conference on Systems Biology (Karolinska Institute, Stockholm, Sweden, 2002).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Computer Science, Duke University, Box 90129, Durham, 27708-0129, North Carolina, USA

    Alexander J Hartemink

Authors
  1. Alexander J Hartemink
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hartemink, A. Reverse engineering gene regulatory networks. Nat Biotechnol 23, 554–555 (2005). https://doi.org/10.1038/nbt0505-554

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt0505-554

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation