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What is principal component analysis?

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Principal component analysis is often incorporated into genome-wide expression studies, but what is it and how can it be used to explore high-dimensional data?

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Figure 1: Principal component analysis (PCA) of a gene expression data set.

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Acknowledgements

I wish to thank the Swedish Foundation for Strategic Research for support through the Lund Strategic Centre for Clinical Cancer Research (CREATE Health).

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Authors and Affiliations

  1. Markus Ringnér is in the Division of Oncology, Department of Clinical Sciences, Barngatan 2, Lund University, 221 85, Lund, Sweden. markus.ringner@med.lu.se,

    Markus Ringnér

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Ringnér, M. What is principal component analysis?. Nat Biotechnol 26, 303–304 (2008). https://doi.org/10.1038/nbt0308-303

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