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Fancy footwork in the sequence space shuffle

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Recent reports on directed evolution broaden the scope of evolutionary enzyme engineering.

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Figure 1: Random circular permutation provides access to some of the riches of sequence space.

Bob Crimi

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  1. Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, 91125, California, USA

    Frances H Arnold

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  1. Frances H Arnold
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Arnold, F. Fancy footwork in the sequence space shuffle. Nat Biotechnol 24, 328–330 (2006). https://doi.org/10.1038/nbt0306-328

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