DNA synthesis by single polymerase molecules has been visualized at the speed of catalysis, heralding a new sequencing technology of unparalleled throughput.
References
Metzker, M.L. Genome Res. 15, 1767–1776 (2005).
Eid, J. et al. Science 323, 133–138 (2009).
Margulies, M. et al. Nature 437, 376–380 (2005).
Bentley, D.R. et al. Nature 456, 53–59 (2008).
Valouev, A. et al. Genome Res. 18, 1051–1063 (2008).
Harris, T.D. et al. Science 320, 106–109 (2008).
Levene, M.J. et al. Science 299, 682–686 (2003).
Soengas, M.S., Gutiérrez, C. & Salas, M. J. Mol. Biol. 253, 517–529 (1995).
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Metzker, M. Sequencing in real time. Nat Biotechnol 27, 150–151 (2009). https://doi.org/10.1038/nbt0209-150
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DOI: https://doi.org/10.1038/nbt0209-150
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