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An enriched look at tyrosine phosphorylation

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Immunoaffinity isolation enables the identification of phosphotyrosine peptides on a global level.

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Figure 1: In the study by Rush et al., the proteome is digested into peptides that are then passed through an anti-phosphotyrosine monoclonal antibody column to extract phosphotyrosine (pTyr)-containing peptides.

Bob Crimi

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Authors and Affiliations

  1. Laboratory of Proteomics and Analytical Technologies, SAIC-Frederick, Inc., National Cancer Institute at Frederick, P.O. Box B, Frederick, 21702-1201, MD, USA

    Thomas P Conrads & Timothy D Veenstra

Authors
  1. Thomas P Conrads
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  2. Timothy D Veenstra
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Conrads, T., Veenstra, T. An enriched look at tyrosine phosphorylation. Nat Biotechnol 23, 36–37 (2005). https://doi.org/10.1038/nbt0105-36

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