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Deep phenotyping predicts Huntington's genotype

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Comprehensive phenotyping of Huntington's disease in mice yields phenotypic signatures of disease-causing genetic variants.

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Figure 1: Strategy to predict complex genotypes from high-dimensional phenotypic data on mouse models of Huntingon's disease.

Kim Caesar/Nature Publishing Group

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Authors and Affiliations

  1. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA

    Douglas M Ruderfer

  2. Department of Genetics and Genomics Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

    Joel T Dudley

Authors
  1. Douglas M Ruderfer
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  2. Joel T Dudley
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Correspondence to Joel T Dudley.

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Competing interests

J.T.D. owns equity options in NuMedii, Inc., Ayasdi, Inc., Solve Bio, Inc., and LAM Therapeutics.

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Ruderfer, D., Dudley, J. Deep phenotyping predicts Huntington's genotype. Nat Biotechnol 34, 823–824 (2016). https://doi.org/10.1038/nbt.3648

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