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Inducing tolerance one antigen at a time

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Autoimmune diseases are reversed in mice using nanoparticles that display disease-associated antigens bound to MHC class II molecules.

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Figure 1: Nanoparticles bearing pMHC complexes activate a known immunosuppressive network.

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Authors and Affiliations

  1. Rafael M. Rezende & Howard L. Weiner are at the Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.,

    Rafael M Rezende & Howard L Weiner

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  1. Rafael M Rezende
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  2. Howard L Weiner
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Correspondence to Howard L Weiner.

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The authors declare no competing financial interests.

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Rezende, R., Weiner, H. Inducing tolerance one antigen at a time. Nat Biotechnol 34, 515–517 (2016). https://doi.org/10.1038/nbt.3573

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