Skip to main content

Advertisement

SpringerLink
Log in

Biological synthesis unbounded?

  • News & Views
  • Published:

From Nature Biotechnology

View current issue Submit your manuscript

Chemical synthesis of specialty and commodity products still reigns supreme but greener, metabolic engineering approaches are gaining ground.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: A decision tree for designing a high-throughput screen for detecting a metabolic product.

References

  1. Galanie, S., Thodey, K., Trenchard, I.J., Filsinger Interrante, M. & Smolke, C.D. Science 349, 1095–1100 (2015).

    Article  CAS  Google Scholar 

  2. Thodey, K., Galanie, S. & Smolke, C.D. Nat. Chem. Biol. 10, 837–844 (2014).

    Article  CAS  Google Scholar 

  3. DeLoache, W.C. et al. Nat. Chem. Biol. 11, 465–471 (2015).

    Article  CAS  Google Scholar 

  4. Fossati, E., Narcross, L., Ekins, A., Falgueyret, J.P. & Martin, V.J. PLoS One 10, e0124459 (2015).

    Article  Google Scholar 

  5. Ehrenberg, R. Nature 521, 267–268 (2015).

    Article  CAS  Google Scholar 

  6. Yim, H. et al. Nat. Chem. Biol. 7, 445–452 (2011).

    Article  CAS  Google Scholar 

  7. Alper, H. & Stephanopoulos, G. Nat. Rev. Microbiol. 7, 715–723 (2009).

    Article  CAS  Google Scholar 

  8. Hsu, P.D., Lander, E.S. & Zhang, F. Cell 157, 1262–1278 (2014).

    Article  CAS  Google Scholar 

  9. National Rearch Council. Industrialization of Biology: A Roadmap to Accelerate the Advanced Manufacturing of Chemicals. http://www.nap.edu/catalog/19001/industrialization-of-biology-a-roadmap-to-accelerate-the-advanced-manufacturing (National Academies Press, 2015).

Download references

Author information

Authors and Affiliations

  1. Brian F. Pfleger is at the University of Wisconsin-Madison, Madison, Wisconsin, USA,

    Brian F Pfleger

  2. Kristala L.J. Prather is in the Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.,

    Kristala L J Prather

Authors
  1. Brian F Pfleger
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kristala L J Prather
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Brian F Pfleger or Kristala L J Prather.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Pfleger, B., Prather, K. Biological synthesis unbounded?. Nat Biotechnol 33, 1148–1149 (2015). https://doi.org/10.1038/nbt.3399

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt.3399

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation