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Opportunities for drug repositioning from phenome-wide association studies

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Figure 1: The three steps in the discovery process.

References

  1. Hebbring, S.J. Immunology 141, 157–165 (2014).

    Article  CAS  Google Scholar 

  2. Denny, J.C. et al. Nat. Biotechnol. 31, 1102–1110 (2013).

    Article  CAS  Google Scholar 

  3. Ye, Z. et al. Eur. J. Hum. Genet. http://dx.doi.org/10.1038/ejhg.2014.123 (30 July 2014).

  4. Novac, N. Trends Pharmacol. Sci. 34, 267–272 (2013).

    Article  CAS  Google Scholar 

  5. Plenge, R.M., Scolnick, E.M. & Altshuler, D. Nat. Rev. Drug Discov. 12, 581–594 (2013).

    Article  CAS  Google Scholar 

  6. Sanseau, P. et al. Nat. Biotechnol. 30, 317–320 (2012).

    Article  CAS  Google Scholar 

  7. Okada, Y. et al. Nature 506, 376–381 (2014).

    Article  CAS  Google Scholar 

  8. Power, A., Berger, A.C. & Ginsburg, G.S. J. Am. Med. Assoc. 311, 2063–2064 (2014).

    Article  CAS  Google Scholar 

  9. Law, V. et al. Nucleic Acids Res. 42, D1091–D1097 (2014).

    Article  CAS  Google Scholar 

  10. Cobanoglu, M.C., Oltvai, Z.N., Taylor, D.L. & Bahar, I. Bioinformatics 31, 131–133 (2015).

    Article  CAS  Google Scholar 

  11. LaBute, M.X. et al. PLoS ONE 9, e106298 (2014).

    Article  Google Scholar 

  12. Liu, X. et al. J. Cheminform. 6, 33 (2014).

    Article  Google Scholar 

  13. Aronson, A.R. & Lang, F.M. J. Am. Med. Inform. Assoc. 17, 229–236 (2010).

    Article  Google Scholar 

  14. A Catalog of Published Genome-Wide Association Studies. http://www.genome.gov/gwastudies. Accessed 1 February 2014.

  15. Sun, X., Han, F., Yi, J., Hou, N. & Cao, Z. Mol. Med. Rep. 7, 1636–1640 (2013).

    Article  CAS  Google Scholar 

  16. Wang, Z.Y. & Zhang, H.Y. Nat. Biotechnol. 31, 1080–1082 (2013).

    Article  CAS  Google Scholar 

  17. Kilicoglu, H., Shin, D., Fiszman, M., Rosemblat, G. & Rindflesch, T.C. Bioinformatics 28, 3158–3160 (2012).

    Article  CAS  Google Scholar 

  18. Griffith, M. et al. Nat. Methods 10, 1209–1210 (2013).

    Article  CAS  Google Scholar 

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Acknowledgements

This project was supported in part by US National Center for Advancing Translational Sciences grant UL1TR000427 and National Library of Medicine grant 1K22LM011938. M.R.-M. was funded through philanthropic support of the Marshfield Clinic Research Foundation's “Dr. John Melski Endowed Physician Scientist” award granted to S.M.L. We thank J. Denny and colleagues for making the PheWAS catalog available online. We also thank D. Wall for project management and R. Stankowski for critical review, editing and comments.

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Author notes

  1. Majid Rastegar-Mojarad & Simon M Lin

    Present address: Present addresses: Biomedical Statistics and Bioinformatics, Mayo Clinic, Rochester, Minnesota, USA and Nationwide Children's Hospital, Columbus, Ohio, USA.,

Authors and Affiliations

  1. Biomedical Informatics Research Center, Marshfield Clinic Research Foundation, Marshfield, Wisconsin, USA

    Majid Rastegar-Mojarad, Zhan Ye & Simon M Lin

  2. School of Pharmacy, University of Wisconsin, Madison, Wisconsin, USA

    Jill M Kolesar

  3. Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, Wisconsin, USA

    Scott J Hebbring

Authors
  1. Majid Rastegar-Mojarad
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  2. Zhan Ye
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  3. Jill M Kolesar
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  4. Scott J Hebbring
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  5. Simon M Lin
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Corresponding author

Correspondence to Scott J Hebbring.

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The authors declare no competing financial interests.

Supplementary information

Supplementary Text and Figures

Supplementary Figures 1 and 2 (PDF 491 kb)

Supplementary Table 1

Complete list of drug-disease pairs including PheWAS association results, gene target, phenotype, candidate drug, significance category, number of supporting references from Medline abstracts and the Clinical Trial Registry, and overlap with GWAS results. (XLSX 4283 kb)

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Rastegar-Mojarad, M., Ye, Z., Kolesar, J. et al. Opportunities for drug repositioning from phenome-wide association studies. Nat Biotechnol 33, 342–345 (2015). https://doi.org/10.1038/nbt.3183

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