Skip to main content
SpringerLink
Log in

Cytokine-driven beta-cell production in vivo

  • News & Views
  • Published:

From Nature Biotechnology

View current issue Submit your manuscript

Transient treatment of diabetic mice with two cytokines induces acinar-to-beta-cell conversion to an extent sufficient to durably restore normoglycemia.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Schematic of cytokine-induced conversion of pancreatic acinar cells into new beta-like cells.

Katie Vicari

References

  1. Baeyens, L. et al. Nat. Biotechnol. 32, 76–83 (2014).

    Article  CAS  Google Scholar 

  2. Pan, F.C. et al. Development 140, 751–764 (2013).

    Article  CAS  Google Scholar 

  3. Thorel, F. et al. Nature 464, 1149–1154 (2010).

    Article  CAS  Google Scholar 

  4. Bramswig, N.C. et al. J. Clin. Invest. 123, 1275–1284 (2013).

    Article  CAS  Google Scholar 

  5. Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J. & Melton, D.A. Nature 455, 627–632 (2008).

    Article  CAS  Google Scholar 

  6. Lee, J. et al. Cell 151, 547–558 (2012).

    Article  CAS  Google Scholar 

  7. Dor, Y., Brown, J., Martinez, O.I. & Melton, D.A. Nature 429, 41–46 (2004).

    Article  CAS  Google Scholar 

  8. Gu, G., Dubauskaite, J. & Melton, D.A. Development 129, 2447–2457 (2002).

    CAS  PubMed  Google Scholar 

  9. Miyatsuka, T. et al. Genes Dev. 20, 1435–1440 (2006).

    Article  CAS  Google Scholar 

  10. Corcoran, R.B. et al. Cancer Res. 71, 5020–5029 (2011).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. and in the Department of Cell and Developmental Biology, Hannah N. Worchel and Mark A. Magnuson are at the Center for Stem Cell Biology, Vanderbilt University, Nashville, Tennessee, USA, Vanderbilt University, Nashville, Tennessee, USA,

    Hannah N Worchel & Mark A Magnuson

  2. Mark A. Magnuson is also in the Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.,

    Mark A Magnuson

Authors
  1. Hannah N Worchel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mark A Magnuson
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mark A Magnuson.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Worchel, H., Magnuson, M. Cytokine-driven beta-cell production in vivo. Nat Biotechnol 32, 63–64 (2014). https://doi.org/10.1038/nbt.2788

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt.2788

  • Springer Nature America, Inc.

Search

Navigation