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Modulating WNT receptor turnover for tissue repair

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New mechanistic insight into the regulation of WNT signaling supports efforts to target this pathway in adult stem cells for regenerative medicine.

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Figure 1: Modulating LGR5+ crypt stem cells with RSpo proteins for regeneration of the gastrointestinal epithelium.

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Authors and Affiliations

  1. Arie Abo is at the California Institute for Regenerative Medicine, San Francisco, California, USA,

    Arie Abo

  2. Hans Clevers is at the Hubrecht Institute, Developmental Biology and Stem Cell Research, Royal Netherlands Academy of Arts and Sciences Utrecht, 3584CT Utrecht, The Netherlands.,

    Hans Clevers

Authors
  1. Arie Abo
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  2. Hans Clevers
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Correspondence to Arie Abo or Hans Clevers.

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The authors declare no competing financial interests.

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Abo, A., Clevers, H. Modulating WNT receptor turnover for tissue repair. Nat Biotechnol 30, 835–836 (2012). https://doi.org/10.1038/nbt.2361

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