Diverse mathematical models combine to create a comprehensive whole-cell computational model of a human pathogen.
References
Karr, J.R. et al. Cell 150, 389–401 (2012).
Tomita, M. Trends Biotechnol. 19, 205–210 (2001).
Ishii, N., Robert, M., Nakayama, Y., Kanai, A. & Tomita, M. J. Biotechnol. 113, 281–294 (2004).
Guyton, A.C., Coleman, T.G. & Granger, H.J. Annu. Rev. Physiol. 34, 13–44 (1972).
Noble, D. Physiology (Bethesda) 19, 191–197 (2004).
Shoda, L. et al. Clin. Exp. Immunol. 161, 250–267 (2010).
Edwards, J.S., Covert, M. & Palsson, B.O. Environ. Microbiol. 4, 133–140 (2002).
Rosen, R. Life Itself: a Comprehensive Enquiry into the Nature, Origin and Fabrication of Life. Complexity in Ecological Systems (Columbia University Press, 2005).
Letelier, J.-C. & Soto-Andrade, J. J. Theor. Biol. 238, 949–961 (2006).
Gunawardena, J. Mol. Biol. Cell 23, 517–519 (2012).
van Noort, V. et al. Mol. Syst. Biol. 8, 571 (2012).
Yus, E. et al. Science 326, 1263–1268 (2009).
Güell, M. et al. Science 326, 1268–1271 (2009).
Kühner, S. et al. Science 326, 1235–1240 (2009).
Dror, R.O., Dirks, R.M., Grossman, J.P., Xu, H. & Shaw, D.E. Annu. Rev. Biophys. 41, 429–452 (2012).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Gunawardena, J. Silicon dreams of cells into symbols. Nat Biotechnol 30, 838–840 (2012). https://doi.org/10.1038/nbt.2358
Published:
Issue Date:
DOI: https://doi.org/10.1038/nbt.2358
- Springer Nature America, Inc.