References
Abstracts Collaborative Meeting of the European Society of Gene and Cell Therapy and the British Society for Gene Therapy. Hum. Gene Ther. 22, A1–A138 (2011).
Bainbridge, J.W. et al. N. Engl. J. Med. 358, 2231–2239 (2008).
Maguire, A.M. et al. N. Engl. J. Med. 358, 2240–2248 (2008).
Maguire, A.M. et al. Lancet 374, 1597–1605 (2009).
Nathwani, A.C. et al. N. Engl. J. Med. 365, 2357–2365 (2011).
Raj, D., Davidoff, A.M. & Nathwani, A.C. Expert Rev. Hematol. 4, 539–549 (2011).
Booth, C., Gaspar, H.B. & Thrasher, A.J. Curr. Opin. Pediatr. 23, 659–666 (2011).
Cartier, N. et al. Science 326, 818–823 (2009).
Cirak, S. et al. Lancet 378, 595–605 (2011).
Aartsma-Rus, A. et al. Eur. J. Hum. Genet. 18, 889–894 (2010).
Jessup, M. et al. Circulation 124, 304–313 (2011).
Sheehy, S.H. et al. Mol. Ther. 19, 2269–2276 (2011).
Schaller, T. et al. PLoS Pathog. 7, e1002439 (2011).
Li, H. et al. Nature 475, 217–221 (2011).
Perez, E.E. et al. Nat. Biotechnol. 26, 808–816 (2008).
Stroncek, D.F. et al. J. Transl. Med. 10, 48 (2012).
Gollamudi, R. et al. Invest. New Drugs 28, 641–649 (2010).
Comins, C. et al. Clin. Cancer Res. 16, 5564–5572 (2010).
Breitbach, C.J. et al. Hum. Gene Ther. 22, A12 (2011).
Kaufman, H.L. & Bines, S.D. Future Oncol. 6, 941–949 (2010).
Heo, J. et al. Mol. Ther. 19, 1170–1179 (2011).
Breitbach, C.J. et al. Nature 477, 99–102 (2011).
Gaspar, H.B. et al. Sci. Transl. Med. 3, 97ra79 (2011).
Hacein-Bey-Abina, S. et al. N. Engl. J. Med. 363, 355–364 (2010).
Gaspar, H.B. et al. Sci. Transl. Med. 3, 97ra80 (2011).
Aiuti, A. et al. N. Engl. J. Med. 360, 447–458 (2009).
Grez, M. et al. Mol. Ther. 19, 28–35 (2011).
Boztug, K. et al. N. Engl. J. Med. 363, 1918–1927 (2010).
Galy, A. & Thrasher, A.J. Curr. Opin. Allergy Clin. Immunol. 11, 545–550 (2011).
Cavazzana-Calvo, M. et al. Nature 467, 318–322 (2010).
Porter, D.L., Levine, B.L., Kalos, M., Bagg, A. & June, C.H. N. Engl. J. Med. 365, 725–733 (2011).
Kochenderfer, J.N. et al. Blood 119, 2709–2720 (2012).
Di Stasi, A. et al. N. Engl. J. Med. 365, 1673–1683 (2011).
Harrington, K.J. et al. Clin. Cancer Res. 16, 4005–4015 (2010).
Senzer, N.N. et al. J. Clin. Oncol. 27, 5763–5771 (2009).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
L.W.S. owns equity in PsiOxus Therapeutics, a biotech company developing an oncolytic group B adenovirus.
Rights and permissions
About this article
Cite this article
Seymour, L., Thrasher, A. Gene therapy matures in the clinic. Nat Biotechnol 30, 588–593 (2012). https://doi.org/10.1038/nbt.2290
Published:
Issue Date:
DOI: https://doi.org/10.1038/nbt.2290
- Springer Nature America, Inc.
This article is cited by
-
Enhance transgene responses through improving cellular uptake and intracellular trafficking by bio-inspired non-viral vectors
Journal of Nanobiotechnology (2020)
-
LentiPro26: novel stable cell lines for constitutive lentiviral vector production
Scientific Reports (2018)
-
Single-step cloning-screening method: a new tool for developing and studying high-titer viral vector producer cells
Gene Therapy (2015)
-
CD133-targeted Gene Transfer Into Long-term Repopulating Hematopoietic Stem Cells
Molecular Therapy (2015)
-
Genome-wide Computational Analysis Reveals Cardiomyocyte-specific Transcriptional Cis-regulatory Motifs That Enable Efficient Cardiac Gene Therapy
Molecular Therapy (2015)