References
Laine, C. et al. Ann. Intern. Med. 147, 275–277 (2007).
Anonymous. Nat. Biotechnol. 30, 371 (2012).
Sena, E.S., van der Worp, H.B., Bath, P.M., Howells, D.W. & Macleod, M. PLoS Biol. 8, e1000344 (2010).
Kola, I. & Landis, J. Nat. Rev. Drug Discov. 3, 711–715 (2004).
Duhem, P.M.M. The Aim and Structure of Physical Theory (Princeton University Press, Princeton, NJ; 1954).
Bath, P.M. et al. Br. J. Pharmacol. 157, 1157–1171 (2009).
Lorente, J.A. & Marshall, J.C. Shock 24, 107–119 (2005).
Clarke, J. et al. Regul. Toxicol. Pharmacol. 50, 2–22 (2008).
Obach, R.S. et al. J. Pharmacol. Exp. Ther. 283, 46–58 (1997).
Ross, J.S. et al. Br. Med. J. 344, d7292 (2012).
Zarin, D.A. et al. J. Am. Med. Assoc. 297, 2112–2120 (2007).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Kimmelman, J., Anderson, J. Should preclinical studies be registered?. Nat Biotechnol 30, 488–489 (2012). https://doi.org/10.1038/nbt.2261
Published:
Issue Date:
DOI: https://doi.org/10.1038/nbt.2261
- Springer Nature America, Inc.
This article is cited by
-
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research
BMC Veterinary Research (2020)
-
Can animal data translate to innovations necessary for a new era of patient-centred and individualised healthcare? Bias in preclinical animal research
BMC Medical Ethics (2015)
-
Industry sponsorship and publication bias among animal studies evaluating the effects of statins on atherosclerosis and bone outcomes: a meta-analysis
BMC Medical Research Methodology (2015)