When human blastocysts are cultured in vitro to derive embryonic stem cells, they undergo profound molecular changes that alter their identity.
References
O'Leary, B. Nat. Biotechnol. 30, 278–282 (2012).
Nichols, J. & Smith, A. Cell Stem Cell 4, 487–492 (2009).
Hanna, J. et al. Cell Stem Cell 4, 513–524 (2009).
Guo, G. et al. Development 136, 1063–1069 (2009).
Chu, L.F., Surani, M.A., Jaenisch, R. & Zwaka, T.P. Curr. Biol. 21, 1759–1765 (2011).
Thomson, J.A. et al. Science 282, 1145–1147 (1998).
Hanna, J. et al. Proc. Natl. Acad. Sci. USA 107, 9222–9227 (2010).
Lengner, C.J. et al. Cell 141, 872–883 (2010).
Okamoto, I. et al. Nature 472, 370–374 (2011).
Tachibana, M. et al. Cell 148, 285–295 (2012).
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Pribluda, A., Hanna, J. Tracing the genesis of human embryonic stem cells. Nat Biotechnol 30, 247–249 (2012). https://doi.org/10.1038/nbt.2139
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DOI: https://doi.org/10.1038/nbt.2139
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