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TALEs of genome targeting

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New tools for site-specific genome targeting in human cells are generated from TALE proteins.

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Figure 1: Engineered TALEs function as programmable transcriptional activators and nucleases in human cells.

References

  1. Bonas, U., Stall, R.E. & Staskawicz, B.J. Mol. Gen. Genet. 218, 127–136 (1989).

    Article  CAS  Google Scholar 

  2. Boch, J. et al. Science 326, 1509–1512 (2009).

    Article  CAS  Google Scholar 

  3. Christian, M. et al. Genetics 186, 757–761 (2010).

    Article  CAS  Google Scholar 

  4. Morbitzer, R., Römer, P., Boch, J. & Lahaye, T. Proc. Natl. Acad. Sci. USA 107, 21617–21622 (2010).

    Article  CAS  Google Scholar 

  5. Miller, J.C. et al. Nat. Biotechnol. 29, 143–148 (2011).

    Article  CAS  Google Scholar 

  6. Zhang, F. et al. Nat. Biotechnol. 29, 149–153 (2011).

    Article  Google Scholar 

  7. Urnov, F.D., Rebar, E.J., Holmes, M.C., Zhang, H.S. & Gregory, P.D. Nat. Rev. Genet. 11, 636–646 (2010).

    Article  CAS  Google Scholar 

  8. Boch, J. & Bonas, U. Annu. Rev. Phytopathol. 48, 419–436 (2010).

    Article  CAS  Google Scholar 

  9. Moscou, M.J. & Bogdanove, A.J. Science 326, 1501 (2009).

    Article  CAS  Google Scholar 

  10. Li, T. et al. Nucleic Acids Res. 39, 359–372 (2011).

    Article  Google Scholar 

  11. Kay, S., Hahn, S., Marois, E., Hause, G. & Bonas, U. Science 318, 648–651 (2007).

    Article  CAS  Google Scholar 

  12. Engler, C., Kandzia, R. & Marillonnet, S. PLoS ONE 3, e3647 (2008).

    Article  Google Scholar 

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Correspondence to Jens Boch.

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Boch, J. TALEs of genome targeting. Nat Biotechnol 29, 135–136 (2011). https://doi.org/10.1038/nbt.1767

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