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Crafting rat genomes with zinc fingers

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Expressing zinc-finger nucleases in zygotes enables targeted transgene integration in the mouse and rat genomes.

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Figure 1: Three principal routes to achieve targeted genome modifications in the rat and other mammalian species.

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Authors and Affiliations

  1. Meng Amy Li & Allan Bradley are at Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom.,

    Meng Amy Li & Allan Bradley

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  1. Meng Amy Li
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  2. Allan Bradley
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Correspondence to Allan Bradley.

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The authors declare no competing financial interests.

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Li, M., Bradley, A. Crafting rat genomes with zinc fingers. Nat Biotechnol 29, 39–41 (2011). https://doi.org/10.1038/nbt.1749

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