The cellular origins of a precancerous condition called Barrett's oesophagus have been unclear. Tracking and analysis of epithelial cells at the affected site could shed light on the problem. See Letter p.529
Notes
References
Jiang, M. et al. Nature 550, 529–533 (2017).
Giroux, V. & Rustgi, A. K. Nature Rev. Cancer 17, 594–604 (2017).
McDonald, S. A., Lavery, D., Wright, N. A. & Jansen, M. Nature Rev. Gastroenterol. Hepatol. 12, 50–60 (2015).
Spechler, S. J. & Souza, R. F. N. Engl. J. Med. 371, 836–845 (2014).
Glickman, J. N., Chen, Y. Y., Wang, H. H., Antonioli, D. A. & Odze, R. D. Am. J. Surg. Pathol. 25, 569–578 (2001).
Cabibi, D. et al. Med. Sci. Monit. 15, CR203–CR210 (2009).
Coleman, H. G., Xie, S.-H. & Lagergren, J. Gastroenterology http://dx.doi.org/10.1053/j.gastro.2017.07.046 (2017).
Phillips, R. W., Frierson, H. F. & Moskaluk, C. A. Am. J. Surg. Pathol. 27, 1442–1447 (2003).
Blokzijl, F. et al. Nature 538, 260–264 (2016).
Ross-Innes, C. S. et al. Nature Genet. 47, 1038–1046 (2015).
Hamilton, S. R. & Yardley, J. H. Gastroenterology 72, 669–675 (1977).
Author information
Authors and Affiliations
Corresponding author
Related links
Rights and permissions
About this article
Cite this article
Zhuang, L., Fitzgerald, R. Origins in the oesophagus. Nature 550, 463–464 (2017). https://doi.org/10.1038/nature24150
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature24150
- Springer Nature Limited