Removing the protein complex cohesin from chromosomes destroys one layer of the genome's 3D structure but leaves another intact. Genome structure is therefore built by independent processes that work together. See Letter p.51
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McCord, R. How to build a cohesive genome in 3D. Nature 551, 38–40 (2017). https://doi.org/10.1038/nature24145
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DOI: https://doi.org/10.1038/nature24145
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