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Vitamin C regulates stem cells and cancer

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It emerges that high levels of vitamin C in blood-forming stem cells influence the number and function of the cells and affect the development of leukaemia, through binding to a tumour-suppressor protein, Tet2. See Article p.476

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Figure 1: The effects of vitamin C on stem-cell biology and leukaemia.

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Authors and Affiliations

  1. Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, 02115, Massachusetts, USA

    Peter G. Miller & Benjamin L. Ebert

  2. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, and at the Broad Institute of MIT and Harvard, Cambridge, Massachusetts

    Peter G. Miller & Benjamin L. Ebert

Authors
  1. Peter G. Miller
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  2. Benjamin L. Ebert
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Correspondence to Benjamin L. Ebert.

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Miller, P., Ebert, B. Vitamin C regulates stem cells and cancer. Nature 549, 462–464 (2017). https://doi.org/10.1038/nature23548

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