Live imaging shows that healthy skin cells surround and expel neighbours that have cancer-promoting mutations, revealing that tissues can recognize and eliminate mutant cells to prevent tumour initiation. See Letter p.334
Notes
References
Brown, S. et al. Nature 548, 334–337 (2017).
Chan, E., Gat, U., McNiff, J. M. & Fuchs, E. Nature Genet. 21, 410–413 (1999).
Rompolas, P. et al. Nature 487, 496–499 (2012).
Prior, I. A., Lewis, P. D. & Mattos, C. Cancer Res. 72, 2457–2467 (2012).
Gailani, M. R. et al. Nature Genet. 14, 78–81 (1996).
Morin, P. J. et al. Science 275, 1787–1790 (1997).
Mills, J. C. & Sansom, O. J. Sci. Signal. 8, re8 (2015).
Burclaff, J., Osaki, L. H., Liu, D., Goldenring, J. R. & Mills, J. C. Gastroenterology 152, 762–766 (2017).
Guerra, C. et al. Cancer Cell 11, 291–302 (2007).
Kon, S. et al. Nature Cell Biol. 19, 530–541 (2017).
Yamamoto, M., Ohsawa, S., Kunimasa, K. & Igaki, T. Nature 542, 246–250 (2017).
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Burclaff, J., Mills, J. Healthy skin rejects cancer. Nature 548, 289–290 (2017). https://doi.org/10.1038/nature23534
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DOI: https://doi.org/10.1038/nature23534
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