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Stem cells

The cost of perpetual youth

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The ability to become nearly any cell type is restricted to eggs, sperm and primitive stem cells in very early embryos. Two studies reveal that maintaining this pluripotent state in vitro comes at a cost. See Letters p.219 & p.224

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Figure 1: Effects of maintaining pluripotency long-term in vitro.

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Authors and Affiliations

  1. the the Huffington Foundation Center for Cell-Based Research in Parkinson's Disease and the Department of Cell, Black Family Stem Cell Institute, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, New York, USA

    Thomas P. Zwaka

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  1. Thomas P. Zwaka
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Correspondence to Thomas P. Zwaka.

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Zwaka, T. The cost of perpetual youth. Nature 548, 165–166 (2017). https://doi.org/10.1038/nature23102

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