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Cancer genomics

Less is more in the hunt for driver mutations

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An analysis of 360 breast-cancer genomes has identified cancer-driving mutations in 9 non-coding DNA sequences called promoters, which regulate gene expression. The result hints at the prevalence of non-coding drivers. See Article p.55

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Figure 1: Improving discovery of cancer-driving mutations in the non-coding genome.

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Authors and Affiliations

  1. Program in Computational Biology and Bioinformatics, and in the Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, 06520, Connecticut, USA

    Sushant Kumar & Mark Gerstein

  2. Department of Computer Science, Yale University,

    Mark Gerstein

Authors
  1. Sushant Kumar
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  2. Mark Gerstein
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Correspondence to Mark Gerstein.

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Kumar, S., Gerstein, M. Less is more in the hunt for driver mutations. Nature 547, 40–41 (2017). https://doi.org/10.1038/nature23085

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