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Division enzyme regulates metabolism

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Cell division requires the action of key regulator proteins called cyclins and CDKs. It emerges that a cyclin–CDK complex can regulate cell metabolism, and targeting this metabolic regulation causes tumour regression in mice. See Letter p.426

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Figure 1: Cell-cycle enzymes can affect cellular metabolism.

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Authors and Affiliations

  1. Department of Biological Chemistry and the Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, 90095, California, USA

    Abigail S. Krall & Heather R. Christofk

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  1. Abigail S. Krall
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  2. Heather R. Christofk
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Correspondence to Heather R. Christofk.

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Krall, A., Christofk, H. Division enzyme regulates metabolism. Nature 546, 357–358 (2017). https://doi.org/10.1038/nature22504

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