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Structural biology

Signalling under the microscope

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G-protein-coupled receptors are biological targets for drug discovery. Developments in cryo-electron microscopy have enabled the solution of the structure of a class B receptor in complex with its signalling protein. Two biologists and a microscopist explain the exciting implications of this work. See Article p.118

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Figure 1: Snapshot of a cellular signalling complex.

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Author information

Authors and Affiliations

  1. Division of Biology and Chemistry, Laboratory of Biomolecular Research, Paul Scherrer Institute, Villigen PSI, Switzerland

    Ching-Ju Tsai & Joerg Standfuss

  2. Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, 94720-3200, California, USA

    Robert M. Glaeser

Authors
  1. Ching-Ju Tsai
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  2. Joerg Standfuss
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  3. Robert M. Glaeser
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Corresponding authors

Correspondence to Ching-Ju Tsai, Joerg Standfuss or Robert M. Glaeser.

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Tsai, CJ., Standfuss, J. & Glaeser, R. Signalling under the microscope. Nature 546, 36–37 (2017). https://doi.org/10.1038/nature22491

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