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Physiology

Bone-derived hormone suppresses appetite

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The glycoprotein lipocalin 2 is released from the bones of mice in a nutrient-dependent manner and binds to receptors in the brain to suppress appetite. This is the first example of bone-derived signals mediating hunger. See Article p.385

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Figure 1: A bone–brain axis modulates hunger.

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References

  1. Mosialou, I. et al. Nature 543, 385–390 (2017).

    Article  CAS  ADS  PubMed  PubMed Central  Google Scholar 

  2. Ferreira, A. C. et al. Prog. Neurobiol. 131, 120–136 (2015).

    Article  CAS  PubMed  Google Scholar 

  3. Flo, T. H. et al. Nature 432, 917–921 (2004).

    Article  CAS  ADS  PubMed  Google Scholar 

  4. Flower, D. R. FEBS Lett. 354, 7–11 (1994).

    Article  CAS  PubMed  Google Scholar 

  5. Cone, R. D. Endocrine Rev. 27, 736–749 (2006).

    Article  CAS  Google Scholar 

  6. Farooqi, I. S. & O'Rahilly, S. Nature Clin. Pract. Endocrinol. Metab. 4, 569–577 (2008).

    Article  CAS  Google Scholar 

  7. Campos, C. A., Shiina, H. & Ritter, R. C. J. Neurosci. 34, 12636–12645 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Roman, C. W., Derkach, V. A. & Palmiter, R. D. Nature Commun. 7, 11905 (2016).

    Article  CAS  ADS  Google Scholar 

  9. Liu, Y. et al. Endocrinology 157, 2380–2392 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Richard D. Palmiter is at the Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA.,

    Richard D. Palmiter

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  1. Richard D. Palmiter
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Correspondence to Richard D. Palmiter.

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Palmiter, R. Bone-derived hormone suppresses appetite. Nature 543, 320–321 (2017). https://doi.org/10.1038/nature21501

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