When some cancer cells delete a tumour-suppressor gene, they also delete nearby genes. It emerges that one of these latter genes has a key metabolic role, revealing a therapeutic opportunity that might be relevant for many tumours. See Letter p.119
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References
Muller, F. L., Aquilanti, E. A. & DePinho, R. A. Trends Cancer 1, 161–173 (2015).
Dey, P. et al. Nature 542, 119–123 (2017).
Lord, C. J. & Ashworth, A. Nature 481, 287–294 (2012).
Farmer, H. et al. Nature 434, 917–921 (2005).
Von Hoff, D. D. et al. N. Engl. J. Med. 369, 1691–1703 (2013).
Conroy, T. et al. N. Engl. J. Med. 364, 1817–1825 (2011).
Vander Heiden, M. G. Nature Rev. Drug Discov. 10, 671–684 (2011).
Ying, H. et al. Cell 149, 656–670 (2012).
Biankin, A. V. et al. Nature 491, 399–405 (2012).
Jiang, P., Du, W., Mancuso, A., Wellen, K. E. & Yang, X. Nature 493, 689–693 (2013).
Chio, I. I. C. et al. Cell 166, 963–976 (2016).
DeNicola, G. M. et al. Nature 475, 106–109 (2012).
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Biffi, G., Tuveson, D. Double trouble for tumours. Nature 542, 34–35 (2017). https://doi.org/10.1038/nature21117
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DOI: https://doi.org/10.1038/nature21117
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