Skip to main content
Log in

In retrospect

Eighty years of stress

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

The discovery in 1936 that rats respond to various damaging stimuli with a general response that involves alarm, resistance and exhaustion launched the discipline of stress research.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Hans Selye outlines the general adaptation syndrome.

Don Graham/Division de la Gestion de Documents et des Archives, Univ. Montréal

Notes

  1. See all news & views

References

  1. Selye, H. Nature 138, 32 (1936).

    Article  ADS  Google Scholar 

  2. Selye, H. Br. Med. J. 1, 1383–1392 (1950).

    Article  CAS  Google Scholar 

  3. Bernard, C. Leçons sur les propriétés physiologiques et les altérations pathologiques des liquides de l'organisme (Baillière, 1859).

    Google Scholar 

  4. Cannon, W. B. The Wisdom of the Body (Norton, 1932).

    Book  Google Scholar 

  5. Sherwin, R. R. & Sacca, L. Am. J. Physiol. Endocrinol. Metab. 245, E157–E165 (1984).

    Article  Google Scholar 

  6. Selye, H. J. Hum. Stress 1, 37–44 (1975).

    Article  CAS  Google Scholar 

  7. Selye, H. Stress in Health and Disease (Butterworth, 1976).

    Google Scholar 

  8. Haslbeck, M. & Vierling, E. J. Mol. Biol. 427, 1537–1548 (2015).

    Article  CAS  Google Scholar 

  9. Park, C.-J. & Seo, Y.-S. Plant Pathol. J. 31, 323–333 (2015).

    Article  CAS  Google Scholar 

  10. Pacak, K. et al. Am. J. Physiol. 275, R1247–R1255 (1998).

    Article  CAS  Google Scholar 

  11. Sterling, P. & Eyer, J. in Handbook of Life Stress, Cognition and Health (eds Fisher, S. & Reason, J.) 629–649 (Wiley, 1988).

    Google Scholar 

  12. Schulkin, J. (ed.) Allostasis, Homeostasis, and the Costs of Physiological Adaptation (Cambridge Univ. Press, 2004).

    Book  Google Scholar 

  13. McEwen, B. S. Physiol. Rev. 87, 873–904 (2007).

    Article  Google Scholar 

  14. Vale, W., Spiess, J., Rivier, C. & Rivier, J. Science 213, 1394–1397 (1981).

    Article  ADS  CAS  Google Scholar 

  15. Fink, G. J. Neuroendocrinol. 23, 107–117 (2011).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to George Fink.

Related links

Related links

Related links in Nature Research

Depression: The best way forward

Psychiatry: A molecular shield from trauma

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Fink, G. Eighty years of stress. Nature 539, 175–176 (2016). https://doi.org/10.1038/nature20473

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature20473

  • Springer Nature Limited

This article is cited by

Navigation