A study of the proteasome — a protein-degradation complex — reveals an evolutionarily conserved pathway that acts through the protein kinase TORC1 to adjust proteasome levels in response to cellular needs. See Letter p.184
This is a preview of subscription content, log in via an institution to check access.
Notes
References
Laplante, M. & Sabatini, D. M. Cell 149, 274–293, (2012).
Rousseau, A. & Bertolotti, A. Nature 536, 184–189 (2016).
Zhang, Y. et al. Nature 513, 440–443 (2014).
Zhao, J., Zhai, B., Gygi, S. P. & Goldberg, A. L. Proc. Natl Acad. Sci. USA 112, 15790–15797 (2015).
Zhao, J., Garcia, G. A. & Goldberg, A. L. Nature 529, E1–E2 (2016).
Finley, D. Annu. Rev. Biochem. 78, 477–513 (2009).
Suraweera, A., Münch, C., Hanssum, A. & Bertolotti, A. Mol. Cell 48, 242–253 (2012).
Hanssum, A. et al. Mol. Cell 55, 566–577 (2014).
Efeyan, A. et al. Nature 493, 679–683 (2012).
Author information
Authors and Affiliations
Corresponding authors
Related links
Rights and permissions
About this article
Cite this article
Chantranupong, L., Sabatini, D. The TORC1 pathway to protein destruction. Nature 536, 155–156 (2016). https://doi.org/10.1038/nature18919
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature18919
- Springer Nature Limited
This article is cited by
-
Expanding the role of proteasome homeostasis in Parkinson’s disease: beyond protein breakdown
Cell Death & Disease (2021)
-
Maintaining the balance of TDP-43, mitochondria, and autophagy: a promising therapeutic strategy for neurodegenerative diseases
Translational Neurodegeneration (2020)