The finding that antibiotics are pumped out of drug-tolerant bacterial cells by the TolC protein complex provides insight into how some cells, known as persisters, survive in the face of antibiotic treatments.
Notes
References
Bigger, J. W. Lancet ii, 497–500 (1944).
Balaban, N. Q., Merrin, J., Chait, R., Kowalik, L. & Leibler, S. Science 305, 1622–1625 (2004).
Maisonneuve, E., Castro-Camargo, M. & Gerdes, K. Cell 154, 1140–1150 (2013).
Veening, J.-W., Smits, W. K. & Kuipers, O. P. Annu. Rev. Microbiol. 62, 193–210 (2008).
Pu, Y. et al. Mol. Cell 62, 284–294 (2016).
Maisonneuve, E., Shakespeare, L. J., Jørgensen, M. G. & Gerdes, K. Proc. Natl Acad. Sci. USA 108, 13206–13211 (2011).
Helaine, S. et al. Science 343, 204–208 (2014).
Verstraeten, N. et al. Mol. Cell. 59, 9–21 (2015).
Author information
Authors and Affiliations
Corresponding author
Related links
Rights and permissions
About this article
Cite this article
Gerdes, K., Semsey, S. Pumping persisters. Nature 534, 41–42 (2016). https://doi.org/10.1038/nature18442
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature18442
- Springer Nature Limited
This article is cited by
-
Birth and Resuscitation of (p)ppGpp Induced Antibiotic Tolerant Persister Cells
Scientific Reports (2019)
-
Persister Cells – a Plausible Outcome of Neutral Coevolutionary Drift
Scientific Reports (2018)