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Depression

Ketamine steps out of the darkness

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The way in which ketamine exerts its antidepressant effects has been perplexing. Evidence that a metabolite of the drug is responsible, and acts on a different target from ketamine, might be the key to an answer. See Article p.481

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Figure 1: Metabolite mediator of ketamine.

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Authors and Affiliations

  1. Roberto Malinow is in the Department of Neurosciences, Division of Biology, School of Medicine, and in the Section of Neurobiology, University of California, San Diego, La Jolla, California 92093, USA.,

    Roberto Malinow

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  1. Roberto Malinow
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Correspondence to Roberto Malinow.

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Malinow, R. Ketamine steps out of the darkness. Nature 533, 477–478 (2016). https://doi.org/10.1038/nature17897

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