Skip to main content
SpringerLink
Log in

Cell biology

Ubiquitination without E1 and E2 enzymes

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

A protein in the pathogenic bacterium Legionella pneumophila has been found to attach the modifying molecule ubiquitin to human proteins, using a mechanism that, surprisingly, does not involve cellular E1 and E2 enzymes. See Letter p.120

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Mechanisms of ubiquitination.

Notes

  1. See all news & views

References

  1. Hershko, A., Ciechanover, A. & Varshavsky, A. Nature Med. 6, 1073–1081 (2000).

    Article  CAS  Google Scholar 

  2. Qiu, J. et al. Nature 533, 120–124 (2016).

    Article  ADS  CAS  Google Scholar 

  3. Schulman, B. A. & Harper, J. W. Nature Rev. Mol. Cell Biol. 10, 319–331 (2009).

    Article  CAS  Google Scholar 

  4. Joazeiro, C. A. P. & Hunter, T. Science 289, 2061–2062 (2000).

    Article  CAS  Google Scholar 

  5. Maculins, T., Fiskin, E., Bhogaraju, S. & Dikic, I. Cell Res. 26, 499–510 (2016).

    Article  CAS  Google Scholar 

  6. Hubber, A. & Roy, C. R. Annu. Rev. Cell Dev. Biol. 26, 261–283 (2010).

    Article  CAS  Google Scholar 

  7. Xu, L. & Luo, Z.-Q. Microbes Infect. 15, 157–167 (2013).

    Article  CAS  Google Scholar 

  8. Bardill, J. P., Miller, J. L. & Vogel, J. P. Mol. Microbiol. 56, 90–103 (2005).

    Article  CAS  Google Scholar 

  9. Barkauskaite, E., Jankevicius, G. & Ahel, I. Mol. Cell 58, 935–946 (2015).

    Article  CAS  Google Scholar 

  10. Haas, A. L. & Rose, I. A. J. Biol. Chem. 257, 10329–10337 (1982).

    Article  CAS  Google Scholar 

  11. Glowacki, G. et al. Protein Sci. 11, 1657–1670 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Sagar Bhogaraju and Ivan Dikic are in the Institute of Biochemistry II, Goethe University School of Medicine, 60590 Frankfurt am Main, Germany, and in the Buchmann Institute for Molecular Life Sciences, Goethe University.,

    Sagar Bhogaraju & Ivan Dikic

Authors
  1. Sagar Bhogaraju
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ivan Dikic
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ivan Dikic.

Related links

Related links

Related links in Nature Research

Cell biology: A guardian angel of cell integrity

Cell biology: Balancing act

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bhogaraju, S., Dikic, I. Ubiquitination without E1 and E2 enzymes. Nature 533, 43–44 (2016). https://doi.org/10.1038/nature17888

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature17888

  • Springer Nature Limited

This article is cited by

Search

Navigation