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Architecture of a protein entry gate

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The TOM complex guides precursor proteins from the cell's cytosolic fluid into organelles called mitochondria. Biochemical analyses reveal the architecture of this complex and show how precursor proteins pass through its narrow pores.

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Figure 1: Architecture of the TOM complex.

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References

  1. Shiota, T. et al. Science 349, 1544–1548 (2015).

    Article  ADS  CAS  Google Scholar 

  2. Neupert, W. J. Mol. Biol. 427, 1135–1158 (2015).

    Article  CAS  Google Scholar 

  3. Künkele, K. P. et al. Cell 93, 1009–1019 (1998).

    Article  Google Scholar 

  4. Model, K., Meisinger, C. & Kühlbrandt, W. J. Mol. Biol. 383, 1049–1057 (2008).

    Article  CAS  Google Scholar 

  5. Liu, C. C. & Schultz, P. G. Annu. Rev. Biochem. 79, 413–444 (2010).

    Article  CAS  Google Scholar 

  6. Ujwal, R. et al. Proc. Natl Acad. Sci. USA 105, 17742–17747 (2008).

    Article  ADS  CAS  Google Scholar 

  7. Qiu, J. et al. Cell 154, 596–608 (2013).

    Article  CAS  Google Scholar 

  8. Lackey, S. W. K. et al. J. Biol. Chem. 289, 21640–21650 (2014).

    Article  Google Scholar 

  9. Rapaport, D. et al. Mol. Cell. Biol. 18, 5256–5262 (1998).

    Article  CAS  Google Scholar 

  10. Shiota, T., Mabuchi, H., Tanaka-Yamano, S., Yamano, K. & Endo, T. Proc. Natl Acad. Sci. USA 108, 15179–15183 (2011).

    Article  ADS  CAS  Google Scholar 

  11. Schmidt, O. et al. Cell 144, 227–239 (2011).

    Article  CAS  Google Scholar 

  12. Noinaj, N., Kuszak, A. J., Balusek, C., Gumbart, J. C. & Buchanan, S. K. Structure 22, 1055–1062 (2014).

    Article  CAS  Google Scholar 

  13. Baud, C. et al. Nature Commun. 5, 5271 (2014).

    Article  ADS  CAS  Google Scholar 

  14. Bragoszewski, P. et al. Proc. Natl Acad. Sci. USA 112, 7713–7718 (2015).

    Article  ADS  CAS  Google Scholar 

  15. Waegemann, K., Popov-Čeleketić, D., Neupert, W., Azem, A. & Mokranjac, D. J. Mol. Biol. 427, 1075–1084 (2015).

    Article  CAS  Google Scholar 

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Correspondence to Dejana Mokranjac or Walter Neupert.

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Mokranjac, D., Neupert, W. Architecture of a protein entry gate. Nature 528, 201–202 (2015). https://doi.org/10.1038/nature16318

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