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Cancer

Opening LOX to metastasis

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New findings implicate the enzyme lysyl oxidase (LOX), secreted by oxygen-deprived breast cancer cells, in inducing bone lesions that precede and facilitate the spread of the cancer cells to the bone. See Letter p.106

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Figure 1: Pre-metastatic niche formation in bone.

Change history

  • 11 May 2023

    The article on which this News & Views commented, ‘The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase’, has now been retracted.

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Authors and Affiliations

  1. Neta Erez is in the Department of Pathology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978 Israel.,

    Neta Erez

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  1. Neta Erez
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Erez, N. Opening LOX to metastasis. Nature 522, 41–42 (2015). https://doi.org/10.1038/nature14529

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