Deletion of the TP53 gene, an event seen in colorectal cancers, often occurs with co-deletion of a gene that encodes an enzyme subunit governing gene transcription. This creates a vulnerability ripe for therapeutic development. See Letter p.697
Notes
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Bradner, J. An essential passenger with p53. Nature 520, 626–627 (2015). https://doi.org/10.1038/nature14390
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DOI: https://doi.org/10.1038/nature14390
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