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Cell signalling

Disarming Wnt

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The secreted enzyme Notum has been found to inhibit the Wnt signalling pathway through removal of a lipid that is linked to the Wnt protein and that is required for activation of Wnt receptor proteins. See Article p.187

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Figure 1: Notum shoots the messenger in Wnt signalling.

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Authors and Affiliations

  1. Department of Developmental Biology, Roel Nusse is at the Howard Hughes Medical Institute, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305-5458, USA.,

    Roel Nusse

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  1. Roel Nusse
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Correspondence to Roel Nusse.

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Nusse, R. Disarming Wnt. Nature 519, 163–164 (2015). https://doi.org/10.1038/nature14208

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