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PLD3 in non-familial Alzheimer's disease

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References

  1. Guerreiro, R. et al. TREM2 variants in Alzheimer's disease. N. Engl. J. Med. 368, 117–127 (2013)

    Article  CAS  Google Scholar 

  2. Pottier, C. et al. High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease. Mol. Psychiatry 17, 875–879 (2012)

    Article  CAS  Google Scholar 

  3. Cruchaga, C. et al. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease. Nature 505, 550–554 (2014)

    Article  CAS  Google Scholar 

  4. Ruiz, A. et al. Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene. Transl. Psychiatr. 4, e358 (2014)

    Article  CAS  Google Scholar 

  5. Ruiz, A. et al. Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia. Neurobiol. Aging 35, 444.e1–4 (2013)

    Article  Google Scholar 

  6. Ramirez, A. et al. SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease. Hum. Mol. Genet. (2014)

  7. Kornhuber, J. et al. Early and differential diagnosis of dementia and mild cognitive impairment: design and cohort baseline characteristics of the German Dementia Competence Network. Dement. Geriatr. Cogn. Disord. 27, 404–417 (2009)

    Article  Google Scholar 

  8. Jessen, F. et al. Prediction of dementia in primary care patients. PLoS ONE 6, e16852 (2011)

    Article  ADS  CAS  Google Scholar 

  9. Herold, C., Steffens, M., Brockschmidt, F. F., Baur, M. P. & Becker, T. INTERSNP: genome-wide interaction analysis guided by a priori information. Bioinformatics 25, 3275–3281 (2009)

    Article  CAS  Google Scholar 

  10. Li, B. & Leal, S. M. Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data. Am. J. Hum. Genet. 83, 311–321 (2008)

    Article  CAS  Google Scholar 

  11. Lambert, J.-C. et al. PLD3 and sporadic Alzheimer's disease risk. Nature 520, http://dx.doi.org/10.1038/nature14036 (2015)

  12. Hooli, B. V. et al. PLD3 gene variants and Alzheimer's disease. Nature 520, http://dx.doi.org/10.1038/nature14040 (2015)

  13. van der Lee, S. J. et al. PLD3 variants in population studies. Nature 520, http://dx.doi.org/10.1038/nature14038 (2015)

  14. Morris, A. P. & Zeggini, E. An evaluation of statistical approaches to rare variant analysis in genetic association studies. Genet. Epidemiol. 34, 188–193 (2010)

    Article  Google Scholar 

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Data collection: J.C., I.H., J.F., M.A., R.B., A.M., M.R.R., J.K., O.P., R.H., L.F., M.H., M.T.H., E.R., S.R.H., M.S., J.W., F.J., L.T., M.B., Al.L.; experimental work: S.H., V.F., A.L., H.W., M.T.; project planning: Ag.R., Al.R., J.C., T.B., S.H., M.M.N.; data analysis: S.H., D.D., An.L., T.B., Al.R., J.C., Ag.R.; administrative, technical or material support: J.C., An.L., H.W., M.T., I.H., J.F., M.A., R.B., A.M., M.R.R., J.K., O.P., M.S., L.T., M.B., W.M., Al.L., Ag.R., Al.R.; critical revision of the manuscript for important intellectual content: S.H., D.D., J.C., V.F., An.L., H.W., M.T., I.H., J.F., M.A., R.B., A.M., M.R.R., J.K., O.P., R.H., L.F., M.H., M.T.H., E.R., S.R.H., M.S., J.W., F.J., T.B., L.T., M.B., W.M., Al.L., Ag.R., M.M.N., Al.R.; drafting of the manuscript: Al.R., M.M.N., S.H., T.B., D.D., Ag.R., J.C.; obtaining funding: W.M., M.M.N., F.J., M.S., M.B., L.T., Ag.R., T.B. and J.C.

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Correspondence to Alfredo Ramirez.

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Heilmann, S., Drichel, D., Clarimon, J. et al. PLD3 in non-familial Alzheimer's disease. Nature 520, E3–E5 (2015). https://doi.org/10.1038/nature14039

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