Skip to main content
SpringerLink
Log in

Structural biology

Calcium-activated proteins visualized

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

The first crystal structures of bestrophin and lipid scramblase proteins cast light on how these protein families transport very different substrates across membranes, yet are both activated by calcium ions. See Articles p.207 & p.213

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Cartoons of an activated lipid scramblase and a chloride channel.

References

  1. Yang, Y. D. et al. Nature 455, 1210–1215 (2008).

    Article  ADS  CAS  Google Scholar 

  2. Caputo, A. et al. Science 322, 590–594 (2008).

    Article  ADS  CAS  Google Scholar 

  3. Schroeder, B. C., Cheng, T., Jan, Y. N. & Jan, L. Y. Cell 134, 1019–1029 (2008).

    Article  CAS  Google Scholar 

  4. Sun, H., Tsunenari, T., Yau, K.-W. & Nathans, J. Proc. Natl Acad. Sci. USA 99, 4008–4013 (2002).

    Article  ADS  CAS  Google Scholar 

  5. Yang, H. et al. Cell 151, 111–122 (2012).

    Article  CAS  Google Scholar 

  6. Suzuki, J., Umeda, M., Sims, P. J. & Nagata, S. Nature 468, 834–838 (2010).

    Article  ADS  CAS  Google Scholar 

  7. Malvezzi, M. et al. Nature Commun. 4, 2367; http://dx.doi.org/10.1038/ncomms3367 (2013).

    Article  ADS  Google Scholar 

  8. Brunner, J. D., Lim, N. K., Schenck, S., Dürst, A. & Dutzler, R. Nature 516, 207–212 (2014).

    Article  ADS  CAS  Google Scholar 

  9. Kane Dickson, V., Pedi, L. & Long, S. B. Nature 516, 213–218 (2014).

    Article  ADS  Google Scholar 

  10. Hartzell, C., Putzier, I. & Arreola, J. Annu. Rev. Physiol. 67, 719–758 (2005).

    Article  CAS  Google Scholar 

  11. Yu, K., Duran, C., Qu, Z., Cui, Y. Y. & Hartzell, H. C. Circ. Res. 110, 990–999 (2012).

    Article  CAS  Google Scholar 

  12. Yang, T. et al. Science 346, 355–359 (2014).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Matt Whorton is at the Vollum Institute, Oregon Health & Science University, Portland, Oregon 97239-3098, USA.,

    Matt Whorton

Authors
  1. Matt Whorton
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Matt Whorton.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Whorton, M. Calcium-activated proteins visualized. Nature 516, 176–178 (2014). https://doi.org/10.1038/nature13944

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature13944

  • Springer Nature Limited

Search

Navigation