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DNA repair

Making the cut

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Analysis of the first step in repairing double-stranded-DNA breaks reveals that the Mre11 enzyme makes a DNA nick at a point separate from the break ends, creating an entry site for further processing by exonuclease enzymes. See Letter p.122

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Figure 1: Resection in the right direction.

References

  1. Cannavo, E. & Cejka, P. Nature 514, 122–125 (2014).

    Article  ADS  CAS  Google Scholar 

  2. Mimitou, E. P. & Symington, L. S. Nature 455, 770–774 (2008).

    Article  ADS  CAS  Google Scholar 

  3. Zhu, Z., Chung, W.-H., Shim, E. Y., Lee, S. E. & Ira, G. Cell 134, 981–994 (2008).

    Article  CAS  Google Scholar 

  4. Cannavo, E., Cejka, P. & Kowalczykowski, S. C. Proc. Natl Acad. Sci. USA 110, E1661–E1668 (2013).

    Article  ADS  CAS  Google Scholar 

  5. Niu, H. et al. Nature 467, 108–111 (2010).

    Article  ADS  CAS  Google Scholar 

  6. Cejka, P. et al. Nature 467, 112–116 (2010).

    Article  ADS  CAS  Google Scholar 

  7. Paull, T. T. & Gellert, M. Mol. Cell 1, 969–979 (1998).

    Article  CAS  Google Scholar 

  8. Lengsfeld, B. M., Rattray, A. J., Bhaskara, V., Ghirlando, R. & Paull, T. T. Mol. Cell 28, 638–651 (2007).

    Article  CAS  Google Scholar 

  9. Garcia, V., Phelps, S. E. L., Gray, S. & Neale, M. J. Nature 479, 241–244 (2011).

    Article  ADS  CAS  Google Scholar 

  10. Lammens, K. et al. Cell 145, 54–66 (2011).

    Article  CAS  Google Scholar 

  11. Lim, H. S., Kim, J. S., Park, Y. B., Gwon, G. H. & Cho, Y. Genes Dev. 25, 1091–1104 (2011).

    Article  CAS  Google Scholar 

  12. Huertas, P., Cortés-Ledesma, F., Sartori, A. A., Aguilera, A. & Jackson, S. P. Nature 455, 689–692 (2008).

    Article  ADS  CAS  Google Scholar 

  13. Alani, E., Padmore, R. & Kleckner, N. Cell 61, 419–436 (1990).

    Article  CAS  Google Scholar 

  14. Wang, H. et al. Mol. Cell 54, 1012–1021 (2014).

    Article  CAS  Google Scholar 

  15. Makharashvili, N. et al. Mol. Cell 54, 1022–1033 (2014).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Lorraine S. Symington is in the Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York 10032, USA.,

    Lorraine S. Symington

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  1. Lorraine S. Symington
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Correspondence to Lorraine S. Symington.

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Symington, L. Making the cut. Nature 514, 39–40 (2014). https://doi.org/10.1038/nature13751

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