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Disease models

Statins give bone growth a boost

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The development of stem-cell-based models of two diseases that cause dwarfism reveals that statins — drugs that are used to treat high levels of blood cholesterol — may also promote cartilage formation and bone growth. See Article p.507

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Figure 1: A cell-based model of impaired bone growth.

References

  1. Yamashita, A. et al. Nature 513 507–511 (2014).

    Article  CAS  ADS  Google Scholar 

  2. Shiang, R. et al. Cell 78, 335–342 (1994).

    Article  CAS  Google Scholar 

  3. Tavormina, P. L. et al. Am. J. Hum. Genet. 64, 722–731 (1999).

    Article  CAS  Google Scholar 

  4. Laederich, M. B. & Horton, W. A. Curr. Opin. Pediatr. 22, 516–523 (2010).

    Article  Google Scholar 

  5. Okita, K. et al. Nature Methods 8, 409–412 (2011).

    Article  CAS  Google Scholar 

  6. Koyama, N. et al. Stem Cells Dev. 22, 102–113 (2013).

    Article  CAS  Google Scholar 

  7. Yasoda, A. et al. Nature Med. 10, 80–86 (2004).

    Article  CAS  Google Scholar 

  8. Lorget, F. et al. Am. J. Hum. Genet. 91, 1108–1114 (2012).

    Article  CAS  Google Scholar 

  9. Eiland, L. S. & Luttrell, P. K. J. Pediatr. Pharmacol. Ther. 15, 160–172 (2010).

    PubMed  PubMed Central  Google Scholar 

  10. Braamskamp, M. J. et al. Circulation 128, A17837 (2013).

    Google Scholar 

  11. Hatano, H., Maruo, A., Bolander, M. E. & Sarkar, G. J. Orthop. Sci. 8, 842–848 (2003).

    Article  CAS  Google Scholar 

  12. Simopoulou, T., Malizos, K. N., Poultsides, L. & Tsezou, A. J. Orthop. Res. 28, 110–115 (2010).

    CAS  PubMed  Google Scholar 

  13. Hunter, A. G., Hecht, J. T. & Scott, C. I. Jr Am. J. Med. Genet. 62, 255–261 (1996).

    Article  CAS  Google Scholar 

  14. Wynn, J., King, T. M., Gambello, M. J., Waller, D. K. & Hecht, J. T. Am. J. Med. Genet. A 143A, 2502–2511 (2007).

    Article  Google Scholar 

  15. Collipp, P. J., Sharma, R. K., Thomas, J., Maddaiah, V. T. & Chen, S. Y. Am. J. Dis. Child. 124, 682–685 (1972).

    CAS  PubMed  Google Scholar 

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Correspondence to Bjorn R. Olsen.

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Olsen, B. Statins give bone growth a boost. Nature 513, 494–495 (2014). https://doi.org/10.1038/nature13750

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