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Old blood stem cells feel the stress

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Ageing is accompanied by deterioration in the haematopoietic stem cells that are responsible for regenerating the blood system. Cellular stress in the aged stem cells could be a cause of this decline. See Letter p.198

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Figure 1: Replication stress in ageing cells.

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Authors and Affiliations

  1. Jiri Bartek and Zdenek Hodny are at the Institute of Molecular Genetics of the ASCR, v.v.i., Prague 142 20, Czech Republic.,

    Jiri Bartek & Zdenek Hodny

  2. J.B. is also at the Danish Cancer Society Research Center, Genome Integrity Unit, Copenhagen DK-2100, Denmark.,

    Jiri Bartek

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  1. Jiri Bartek
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  2. Zdenek Hodny
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Correspondence to Jiri Bartek or Zdenek Hodny.

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Bartek, J., Hodny, Z. Old blood stem cells feel the stress. Nature 512, 140–141 (2014). https://doi.org/10.1038/nature13652

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