Production of blood stem cells from reprogrammed adult cells is notoriously difficult. It emerges that a supportive microenvironment may be crucial for their efficient generation. See Article p.312
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Lucas, D., Frenette, P. Reprogramming finds its niche. Nature 511, 301–302 (2014). https://doi.org/10.1038/nature13516
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DOI: https://doi.org/10.1038/nature13516
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