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Natural-born killers unleashed

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The finding that phosphoinositide-3-OH kinase δ restrains the antitumour immune response by promoting the action of suppressive immune cells may broaden the applicability of drugs targeting this enzyme to multiple cancers. See Letter p.407

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Figure 1: Inhibition of PI(3)Kδ releases immune suppression.

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Authors and Affiliations

  1. Department of Molecular Biotechnology and Health Sciences, Emilio Hirsch is at the Molecular Biotechnology Center, University of Turin, 10126 Turin, Italy.,

    Emilio Hirsch

  2. Department of Molecular Biotechnology and Health Sciences, Francesco Novelli is at the Center for Experimental Research and Medical Studies, University of Turin.,

    Francesco Novelli

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  1. Emilio Hirsch
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  2. Francesco Novelli
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Correspondence to Emilio Hirsch or Francesco Novelli.

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Hirsch, E., Novelli, F. Natural-born killers unleashed. Nature 510, 342–343 (2014). https://doi.org/10.1038/nature13503

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