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Immunology

When lymphocytes run out of steam

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The finding that absence of the enzyme CTPS1 underlies a form of human immunodeficiency highlights the role of metabolism in immune responses and suggests avenues for treating diseases such as leukaemia. See Letter p.288

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Figure 1: Regulation of lymphocyte activation by CTPS1.

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Authors and Affiliations

  1. André Veillette and Dominique Davidson are in the Laboratory of Molecular Oncology, Institut de recherches cliniques de Montréal, Montreal, Quebec H2W1R7, Canada.,

    André Veillette & Dominique Davidson

  2. A.V. is also in the Department of Medicine, University of Montreal and the Department of Medicine, McGill University, Montreal.,

    André Veillette

Authors
  1. André Veillette
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  2. Dominique Davidson
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Correspondence to André Veillette.

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Veillette, A., Davidson, D. When lymphocytes run out of steam. Nature 510, 222–223 (2014). https://doi.org/10.1038/nature13346

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