Tumour spread is the main cause of death in patients with melanoma. Exposure of melanoma to ultraviolet radiation has now been found to cause an inflammatory response that drives the formation of distant metastases. See Letter p.109
References
Hodis, E. et al. Cell 150, 251–263 (2012).
Bald, T. et al. Nature 507, 109–113 (2014).
Quail, D. F. & Joyce, J. A. Nature Med. 19, 1423–1437 (2013).
Kowanetz, M. et al. Proc. Natl Acad. Sci. USA 107, 21248–21255 (2010).
Huh, S. J., Liang, S., Sharma, A., Dong, C. & Robertson, G. P. Cancer Res. 70, 6071–6082 (2010).
Robbins, P. F. et al. Nature Med. 19, 747–752 (2013).
van Rooij, N. et al. J. Clin. Oncol. 31, e439–e442 (2013).
Wolchok, J. D. et al. N. Engl. J. Med. 369, 122–133 (2013).
Couzin-Frankel, J. Science 342, 1432–1433 (2013).
Coussens, L. M., Zitvogel, L. & Palucka, A. K. Science 339, 286–291 (2013).
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Coffelt, S., de Visser, K. Inflammation lights the way to metastasis. Nature 507, 48–49 (2014). https://doi.org/10.1038/nature13062
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DOI: https://doi.org/10.1038/nature13062
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